Further evidence stemming from human induced pluripotent stem cells (iPSCs)-derived AD neurons indicated significantly decreased phosphorylation levels of ULK1 (Unc-51 Like Autophagy Activating Kinase 1) and TBK1, thereby suggesting that the initiation of the mitophagy process is impaired (Fang et al., 2019). Here, ULK1 is linked to Alzheimer disease.