In the three Caribbean islands being an APOE-ε4 carrier increases the risk to develop dementia by two folds (SHR 2.03 [1.32-3.11]); in Caucasian populations the risk among APOE-ε4 carriers is 10 to 15 times higher than in non APOE-ε4 carriers (28, 30, 31). Here, APOE is linked to dementia.