APOE and Alzheimer disease: To date only 3% of genetics studies in AD have been done in Hispanics population; (32, 33) like APOE-ε4, other genetic variants previously described in Caucasians (e.g., TREM2, SORL1, ABCA7) may have a differential risk among the Hispanic population; therefore the influences of genetic risk factors in Caribbean Hispanics should be explored in future studies.