As expected, we found that HPDL was strongly associated with genes associated with in mitochondria, including the TCA cycle, OXPHOS, and a series of metabolic diseases with mitochondrial dysfunction, such as Parkinson’s disease, Alzheimer’s disease, nonalcoholic fatty liver disease(NAFLD), and Huntington’s disease (44–47). This evidence concerns the gene HPDL and early-onset autosomal dominant Alzheimer disease.