To test whether ALDH7A1 plays an important role of tumor growth, PDAC cell lines with ALDH7A1 knockdown were inoculated into the nude mouse and compared tumor growth with wild type cell lines (Figure 1D-I and Figure S1F and G). MIA PaCa-2 cell line with ALDH7A1 knockdown showed over 30% reduction of tumor growth (Figure 1D-F and Figure S1F and H) as well as AsPC-1 cell line with ALDH7A1 knockdown showed complete loss of tumor growth (Figure 1G-I and Figure S1G). This evidence concerns the gene ALDH7A1 and neoplasm.