Double-hit lymphomas (DHL), characterized by the rearrangement of c-Myc and Bcl-2 and/or Bcl-6, account for 5-15% of DLBCL; c-Myc also can be overexpressed without genetic rearrangements and is associated with concomitant Bcl-2 expression, resulting in a “double-expresser” phenotype 9, 11. The gene discussed is MYC; the disease is diffuse large B-cell lymphoma.