DICER1 and colorectal carcinoma: Such activation could be retained in Mut3 (site C mutant) but lost in Mut1 (site A mutant) and Mut2 (site B mutant), suggesting that p63 may bind to sites A and B. Using primers covering sites A and B (Promoter AB), our ChIP assays showed that p63 could bind to this region under normoxia, while hypoxia impeded the binding of p63 to the Dicer promoter (Figure 5C), suggesting that it is an in situ binding region for p63 in the CRC cells.