Overexpression of Pin1 could inhibit degradation of α-synuclein, enhance the half-life and insolubility of α-synuclein, and contribute to the formation of debris inclusion bodies of α-synuclein 75(Figure 2B). Therefore, it can be speculated that inhibitors targeting Pin1 may alleviate the process of PD. The gene discussed is PIN1; the disease is Parkinson disease.