PIN1 and neoplasm: Pin1 induces angiogenesis by facilitating expression of VEGF and inhibition of Pin1 by RNAi significantly suppresses angiogenesis 40, 41; Pin1 sustains proliferative signaling and evades growth suppression by activating growth-promoting regulators and inactivating growth-inhibitory regulators 22; Pin1 promotes migration and invasion by regulating NOTCH1 42, TGF-β 43, β-catenin 44, and BRD4 45; Pin1 inhibits apoptosis of tumor cells by increasing the anti-apoptotic function of anti-apoptotic proteins and suppressing pro-apoptotic factors 46, 47.