ANGPTL8 and Insulin resistance: However, this observation was quickly challenged and proved to be incorrect by following studies which found that Angptl8 knockout mice exhibited no abnormalities in terms of glucose homeostasis and/or in beta cell expansion in response to HFD- or insulin receptor antagonist S961-induced insulin resistance 75, and liver-specific overexpression of Angptl8 did not increase beta cell proliferation in mice 76.