SEMA3B and esophageal squamous cell carcinoma: It is well known that Sema3B is involved in the regulation of apoptosis and cell growth in different tumor types; indeed Sema3B can block ESCC cells at the G1/S checkpoint through inhibition of the PI3K/AKT signaling transduction pathway, upregulation of p53 and p21 expression and downregulation of cyclin D1 expression.