SEMA3B and gastric cardia adenocarcinoma: Also in gastric cardia adenocarcinoma (GCA) the loss of heterozygosity in chromosome 3p is one of the most frequent events, likely to impact on the expression of putative tumor suppressor genes, including SEMA3B. Notably, miR-6872 was identified within an intron of SEMA3B gene 61; notably, intronic miRNAs are co-expressed and may play synergetic role with their host genes.