SEMA4D and metastatic malignant neoplasm in the lymph nodes: These findings are consistent with those of a subsequent study, which further revealed that the expression of Sema4D-receptor PlexinB1 in CRC samples correlated with lymph node metastasis; moreover, the combined elevated expression of both Sema4D and PlexinB1 was found to be a stronger independent risk factor for disease relapse, in a multivariate analysis 67.