Consistently, the PaO2 levels of the IPF model mice administered with Fab'-conjugated dual siRNA (siPTPN13 and siNOX4)-loaded micelles was much higher than that of mice treated with saline or Fab'-conjugated single siRNA (PTPN13 or NOX4)-loaded micelles (Figure 8B). This evidence concerns the gene NOX4 and idiopathic pulmonary fibrosis.