NOX4 and idiopathic pulmonary fibrosis: Importantly, the fibrosis score in the Fab'-conjugated dual siRNA-loaded micelle treatment group was notably lower than that in the Fab'-conjugated single siRNA (PTPN13 or NOX4)-loaded micelle treatment group (76% and 72% decrease, respectively, Figure 8E), suggesting that the codelivery of dual siRNA (PTPN13 and NOX4) had a better therapeutic effect than single siRNA on the IPF mice.