GEM and pancreatic neoplasm: To further evaluate the therapeutic benefit of FST in combination with gemcitabine in vivo, we established an orthotopic mouse model of pancreatic cancer and administered purified recombinant human FST along with gemcitabine according to the regimen outlined in Figure 6G. The in vivo data showed that neither FST nor gemcitabine alone influenced the growth of BxPC-3-Gem xenograft tumors compared to the control group (Figure 6H-K).