Conversely, overexpression of MT1G in gemcitabine resistant PDAC cells (Figure 1J, Figure S1E) led to the loss of cancer stemness properties as shown by decreased cell markers expressions (Figure 1K-L), sphere formation ability (Figure 1M) and cells' viability in response to gemcitabine (Figure 1N, Figure S1F). The gene discussed is MT1G; the disease is cancer.