PHB2 and non-small cell lung carcinoma: What is noteworthy is that overexpression of PHB2 promoted tumorigenesis in NSCLC cells, while deficiency of PHB2 suppressed the tumorigenesis of NSCLC in vitro and in vivo, which is similar to the effect of PHB2 on tumorigenesis in other tumor types 10, 11, 41, 42.