In the high-Siglec15 group, activities of the majority of the steps in the cycle were found to be downregulated, including the release of cancer cell antigens (Step 1), priming and activation (Step 3), and trafficking of immune cells to tumors (Step 4) (CD8 T cell recruiting, Macrophage recruiting, Th1 cell recruiting, NK cell recruiting, DC recruiting, and TH17 recruiting) Siglec15(Figure 3B, Table S3). The gene discussed is SIGLEC15; the disease is cancer.