The novel locus rs678741, which is near the region encoding an antisense transcript of the LBX1 gene, was associated with AIS susceptibility but not with curve severity in the Chinese population (Zhu et al., 2015) Recently, a study on the association of rs678741 with AIS curve progression also failed to replicate the association in a Chinese population (Man et al., 2019). This evidence concerns the gene LBX1 and androgen insensitivity syndrome.