CD1D and neoplasm: Classical invariant NKT (iNKT) cells are CD1d-restricted Vα24/Vβ11+α-galactosylceramide (α-GalCer)-reactive T cells and Type II NKT cells are thought to have regulatory functions rather than an anti-tumor immune functionality whereas NKT-like cells are CD1d-independent and express diverse T-cell receptors (TCRs) (23).