GPRC6A and eunuchism: Additionally, in patients with primary testicular failure from a heterozygous missense variant in the transmembrane domain of GPRC6A (F464Y) resulting in interference in the GPRC6A signaling pathway, glucose intolerance accompanies the reproductive hormone deficit, a phenotype analogous to those found in ONC- and GPRC6A-deficient mice (176, 210, 212, 220).