Moreover, while obese men with low total T (and low SHBG) but normal free T do not develop symptoms of hypogonadism and often remits to eugonadism, obese men with incident biochemical secondary hypogonadism, symptomatic androgen deficiency takes place when there is a combination of both low total and free T, suggesting to shift the focus not only on total T but also on free T in the diagnosis of hypogonadism, in order to avoid the over diagnosis of hypogonadism in obese patients (94). The gene discussed is SHBG; the disease is hypogonadism.