In a meta-analysis on individuals with diabetes (T1DM or T2DM), analysis of bone turnover markers, showed significantly reduced levels of serum osteocalcin (OCN) and C-terminal telopeptide (CTX), although other markers, including bone-specific alkaline phosphatase (BAP), did not differ from those without diabetes (20). The gene discussed is CYP27A1; the disease is type 2 diabetes mellitus.