In the USP8 mutant group, 17-AAG inhibited POMC translation significantly (74% inhibition, p=0.02); While a trend towards reduced POMC expression was noted in the wild type group (63%inhibition, p=0.06), which meant the therapeutic validity manifested on function damage in tumor cells carrying the USP8 mutant were more sensitive. This evidence concerns the gene USP8 and neoplasm.