They found that SIRT1 activation by resveratrol could deacetylate FOXO1 and enhance FOXO1 DNA binding at the Ras-related protein Rab-7 (Rab7, a crucial factor in the maturation of autophagosomes and their fusion with lysosomes) promoter region to ameliorate dysfunctional autophagic flux in the hearts of diabetic mice, suggesting that the effect of the SIRT1/FOXO1/Rab7 axis on autophagic flux may be a therapeutic strategy for the treatment of DCM (10). The gene discussed is FOXO1; the disease is familial dilated cardiomyopathy.