Interestingly, in ARVC type V, the most aggressive heterozygous form of ARVC/D that is predominantly associated with a mutation (p.S358L) in transmembrane protein 43 (TMEM43) (a non-desmosomal gene), there is a signal that intense exercise increases ventricular arrhythmias only in females (p = 0.053) (Dominguez et al., 2020). The gene discussed is TMEM43; the disease is Arrhythmogenic right ventricular dysplasia.