Therefore, the present study sought to use SHR as ADHD model and WKY rat as normal control to investigate the possible underlying neuroinflammatory mechanisms of ADHD and explore the effects of ASDZL on behavioral performance, as well as inflammatory factors, immune cells in the brain, BBB and inflammation-related MAPK and NF-κB signaling pathways in the PFC and hippocampus of SHRs. The gene discussed is NFKB1; the disease is attention deficit-hyperactivity disorder.