PPARA and Hepatic fibrosis: Our previous studies have demonstrated that OEA could improve high fat diet-induced liver steatosis in rats, and also can significantly alleviate methionine choline-deficient diet-induced and thioacetamide-induced liver fibrosis through PPAR-α mediated inhibition of hepatic stellate cells activation (Li et al., 2015a; Chen et al., 2015).