Like many other alkaloids, evidence suggests that aloperine exerts therapeutic effect on various cancer types such as colon cancer, prostate cancer, thyroid cancer and breast cancer etc. Mechanistically, aloperine induces cell apoptosis and suppresses tumor migration through various signaling pathways including Ras/Erk, PI3K/Akt and MMPs. The gene discussed is AKT1; the disease is malignant colon neoplasm.