AKT1 and thyroid cancer: For instance, aloperine treatment inhibits proliferation and induces apoptosis of human breast cancer line via blocking Ras/Erk signaling (Tian et al., 2018); as well as for thyroid cancer cell lines, multiple myeloma cell lines and osteoscarcoma MG-63 and U2OS cell lines, inactivation of PI3K/Akt pathway is predominantly involved (Wang et al., 2015; Chen et al., 2018; Lee et al., 2018).