MAPT and Alzheimer disease: However, in our most recent work with these new Spanish colonies of 3xTg-AD mice, and also studying naturally occurring long-term isolation due to loss of partners in an aged scenario, we found that tau pathology of 3xTg-AD mice was enhanced, albeit did not reach the statistical significance, probably due to a celing effect (Muntsant and Giménez-Llort, 2020a).