In brains without AD, decline in growth factors with aging, such as VEGF, fibroblast growth factor (FGF-1 and FGF-2), and angiopoietin, yield slow recovery in tissue wound injuries due to reduced angiogenic capabilities (Ambrose, 2017), or display reduced angiogenesis in response to hypoxia (Benderro and Lamanna, 2011). This evidence concerns the gene VEGFA and Alzheimer disease.