Furthermore, the GCKR p.Leu446Pro variant (rs1260326[T]) associates with a lower risk of type 2 diabetes (Ncases = 36,710, Ncontrols = 663,962; OR = 0.94 [0.93–0.96], P = 1.4 × 10−10) (Supplementary Data 14). The gene discussed is GCKR; the disease is type 2 diabetes mellitus.