JUN and cancer: Broadly enriched motifs revealed highly connected, combinatorially acting master regulators, including HNF1A in the liver, kidney and pancreas (with NR5A2)32; AP-1 (also known as JUN) or JDP2 in immune, bone and cancer samples33; and TEAD3, paired alternately with MYF6 (myosatellite), TFAP2A (placenta) and AP-1 (stromal) (Extended Data Fig. 7d, e).