To define the functional relevance of phenotypic changes induced by IgA transcytosis in ovarian cancer cells, we expressed the cancer testis antigen NY-ESO-1 in HLA-A2+FSHR+ OVCAR3 HGSOC cells, as well as an HLA A2-restricted T cell receptor (TCR) in human T cells that recognizes SLLMWITQC (which corresponds to amino acids 157–165 of NY-ESO-1)13. The gene discussed is CD79A; the disease is ovarian cancer.