The anti-tumour effects of BDNF-specific antibodies were retained upon removal of the Fc domain (which suggests the neutralization of secreted BDNF), and pepsinized anti-TSPAN7 antibodies lost their anti-tumour activity, which is suggestive of antibody-dependent cellular cytotoxicity or phagocytosis (Fig. 3f). Here, BDNF is linked to neoplasm.