The fibrogenic genes Pdgfb and Serpine1 [plasminogen activator inhibitor 1 (Pai1)] and the extracellular matrix-related gene Col1a1 were all upregulated in the livers of Charles River animals with NASH compared to Envigo animals (p = 0.0071, p < 0.0001 and p = 0.0003, respectively). The gene discussed is SERPINE1; the disease is metabolic dysfunction-associated steatohepatitis.