PNPLA3 and metabolic dysfunction-associated steatotic liver disease: Furthermore, several genetic variants have been associated with NAFLD development and progression, especially patatin-like phospholipase domain-containing protein 3 (PNPLA3), transmembrane 6 superfamily member 2 (TM6SF2), membrane bound O-acyltransferase domain-containing 7 (MBOAT7) and the glucokinase regulator (GCKR) gene locus28.