DAXX and neoplasm: Subgroup T2 represented 42.9% of the cohort; tumours in this subgroup were enriched for mutations in ATRX and DAXX (p-adj ≤ 0.003, Fig. 1c), were significantly larger than tumours in the other two subgroups (p-adj ≤ 0.0003, Fig. 1d), had longer telomeres (p-adj ≤ 0.00008, Fig. 1e) and presented a high frequency of alternative lengthening of telomeres (p-adj ≤ 0.0001, Fig. 1a).