MEN1 and neoplasm: In our cohort, the PDX1 gene presented hypermethylated CpG sites in the tumours in subgroups T2 and T3 (mutant ATRX/DAXX/MEN1) compared to tumours in the subgroup T1, which are mainly wild-type for those genes and this subgroup was enriched for functional tumours (Supplementary Fig. 7d, e).