Tumours in subgroup T3 harboured mutations in MEN1 (contained 30.9% of the cohort), had a higher proportion of G1 tumours (p-adj = 0.001, Fig. 1a) and a lower frequency of extra-pancreatic spread, perineural and vascular invasion (Fig. 1g–i), suggesting a subgroup of tumours with better prognosis. This evidence concerns the gene MEN1 and neoplasm.