Although body weight was not changed (Fig. 2A), reductions in impaired glucose tolerance, fasting insulin level and insulin resistance represented by the HOMA-IR value were indeed observed in the AdipoRon-administered group compared to the solvent-administered group (Fig. 2B–E), confirming the efficacy of AdipoRon as an antidiabetic drug. Here, INS is linked to Impaired glucose tolerance.