As observed in human pancreatic cancer MIAPaCa-2 cells29, AdipoRon induced cytoplasmic swelling with large pieces blebbing from the plasma membrane and eventual cytolysis featuring necrotic cell death (Fig. 4D, Supplementary Fig. S1) and transiently increased the phosphorylation of ERK1/2 (Fig. 4B). Here, MAPK3 is linked to familial pancreatic carcinoma.