HSF4 and Alzheimer disease: Moreover, many candidate genes were related to response to stress (SULF2, CADPS2, NOX3, GNAO1, HSF4, AMFR, and CNOT1) and regulation of nervous system (TENM4, VSNL1, CLSTN1, RIT2, TCF4, SKOR2, and NDRG4), which might indicate the significant role of response to stimulus during the AD development (Supplementary Dataset S2).