Our results revealed several candidate genes related to heart (FHOD3, TENM4, WNT11 and NDRG4), liver (SULF2, SRSF5 and IGF2R) and kidney (SULF2 and WNT11) developments (Supplementary Dataset S2), which might be associated with the clinical signs caused by AD in these tissues86. Here, TENM4 is linked to Alzheimer disease.