Within this category, variants in the HIP1, TNFRSF13B, PRKCB, PRRX1, DSE, and PLD4 loci were associated with SLE only in East Asians and variants in TYK2 and NEURL4-ACAP1 only in Europeans (P < 5.0E−08 in one ancestry but P > 0.01 in the other, with non-overlapping of the 95% CIs of the ORs). This evidence concerns the gene TYK2 and systemic lupus erythematosus.