Annexin V/PI assays further indicated that RG@M-γ-CD CNP treatment efficiently compromised the survival of CRC cells, inducing higher proportion of apoptosis compared with other groups (47.7 ± 5.3% and 40.8 ± 7.4% for CT26 and HT29, respectively) (Fig. 3e–h). Here, ANXA5 is linked to colorectal carcinoma.