ACSL4 and cardiomyopathy: In addition, ACSL4 was upregulated in human ischemic intestinal tissues compared with that in healthy tissues, and liproxstatin-1 and siRNA to inhibit ischemia/hypoxia-induced ACSL4 ameliorated I/R-induced intestinal injury.56 12/15-LOX knockout mice can protect neurons against cerebral ischemic injury.281 The heart after acute and chronic I/R is accompanied by severe cardiomyopathy.