Nrf2 is responsible for regulating several antioxidant genes.143 Importantly, almost all genes implicated in ferroptosis are transcriptionally regulated by Nrf2, including genes of glutathione regulation, NADPH regeneration, and iron regulation.144–147 Moreover, Nrf2 indirectly modulates the lipids, whose abundance contributes to ferroptosis sensitivity.6,148 Consequently, Nrf2 activation results in resistance to ferroptosis in cancer cells,98,149 and other cell types.150. Here, NFE2L2 is linked to cancer.