Isotope-reinforced (deuterated) PUFA (D-PUFA) is effective in reducing lipid peroxidation and Aβ level in the APP/PS1 transgenic mouse model of Alzheimer’s disease.232 Alpha-Lipoic acid (ALA), a fat-soluble and water-soluble antioxidant and also a naturally occurring enzyme cofactor with reducing lipid peroxidation properties, can significantly alleviate AD pathology in P301S tau transgenic mice with alleviated properties of ferroptosis.233 Similarly, 2000 IU/d of α-toc compared with placebo resulted in a slower functional decline among patients with mild to moderate AD.234. Here, MAPT is linked to Alzheimer disease.