NCOA4 and acute myeloid leukemia: NCOA4 is a selective cargo receptor for the autophagic turnover of ferritin by lysosomes.67 Genetic and pharmacological inhibition of NCOA4 can protect cells from ferroptosis via reducing cellular labile iron.9 Inhibition of lysosomal function, the endpoint of autophagy flux, can significantly block erastin-induced ferroptosis in both MEFs and HT1080 cells.9 Dihydroartemisinin also promotes ferroptosis by inducing ferritinophagy and increasing the labile iron pool in acute myeloid leukemia.164