STXBP5 and non-small cell lung carcinoma: On the other hand, studies have revealed that STXBP5-AS1 encodes a long noncoding RNA, which inhibits cell proliferation, migration, and invasion via preventing the phosphatidylinositol 3 kinase/protein kinase B (PI3K/AKT) signaling pathway against STXBP5 expression in non-small-cell lung carcinoma and gastric cancer cells [49, 50].