In addition, four novel and previously undetermined molecular entities designated respectively as CNS neuroblastoma with forkhead box R2 “CNS NB-FOXR2”, “CNS Ewing sarcoma family tumor with CIC alteration (CNS EFT-CIC),” “CNS high-grade neuroepithelial tumor with MN1 alteration (CNS HGNET-MN1),” and “CNS high-grade neuroepithelial tumor with BCOR alteration (CNS HGNET-BCOR)” were identified and characterized in detail. The gene discussed is BCOR; the disease is neuroepithelial neoplasm.