Transcriptome signatures of GBM_MYCN were characterized by genes involved in RNA replication, ribosome biogenesis and cell cycle activation; GBM_G34—with Fanconi anaemia, FoxO signalling and lysine degradation, and EPN_RELA—with inositol metabolism, WNT, SHH, HIF-1 and basal cell carcinoma signaling pathways (Fig. 4). Here, SHH is linked to Fanconi anemia.