In the present exploratory study, we measured plasma levels of 182 circulating CVD- and tumor related (Olink CVD III and ONC II panel) proteins in a total of 186 samples (at baseline and follow-up) from 95 DLBCL patients treated with R-CHOP/R-CHOEP (CHOP plus etoposide). Here, DDIT3 is linked to neoplasm.