Interestingly, alteration of Nrg1/ErbB4 signaling is implicated in epilepsy animal models and human patients [18–20], and disruption of Nrg1/ErbB4 signaling pharmacologically and/or genetically promotes kindling progression, which results in increased spontaneous seizures in kindling epilepsy model [18]. The gene discussed is ERBB4; the disease is epilepsy.