Results from this 6-month, randomized, controlled trial on Chinese adults with obesity showed that weight management with regular guidance by physicians, dietitians, and health managers is feasible and effective for improvement of body weight, BMI, body composition parameters (BFM and VFA), liver function, blood lipid profiles, and insulin resistance in all participants. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.