We analyzed the associations between 580 genes in the OSAM1 and OSAM2 modules and AML patients’ OS in the TCGA and OHSU datasets using many statistical methods and identified set of genes was significantly associated with OS in AML patients, such as FNDC3B, VSTM1, PLA2G4A, GOLGA3 and CALR. The PLA2G4A gene encodes a member of the cytosolic phospholipase A2 group IV family which plays an important role the regulation of hemodynamics, inflammatory responses and other intracellular pathways [22]. The expression of PLA2G4A is up-regulated in a wide range of cancer types [23–26]. Here, VSTM1 is linked to acute myeloid leukemia.