MEG3 and colorectal carcinoma: Gu et al. demonstrated that MEG3 could regulate matrix metalloproteinase-related genes [12], specifically, scientists confirmed that overexpressed MEG3 down-regulate the expressions of matrix metalloproteinases (MMP-2, MMP-9) and up-regulate the expression of its inhibitory gene TIMP-2 to inhibitthe invasion of CRC cells [12].