By combining the mRNA and protein profiling data, we purpose new IDD related interacting RNA–protein network and validated key regulators (TNFAIP6, CHI3L1, KRT19, DPT, COL6A2 and COL11A2) with potential functional roles in the IDD process, but the detailed mechanism is up to further investigation and validation. Here, TNFAIP6 is linked to intervertebral disk degenerative disorder.