In the training cohort (248 patients), high preoperative AGLR level was positively correlated with serum AFP level (> 20 ng/ml) (p < 0.001), tumor size > 5 cm (p < 0.001), multiple tumors (p = 0.035), TNM stage III-IV (p < 0.001), presence of MVI (p < 0.001). This evidence concerns the gene AFP and neoplasm.