A mouse model of hormone receptor-positive breast cancer suggested that prior gut dysbiosis in the mice led to a significant increase in tumor dissemination in the blood, lungs, and distal lymph nodes.140 This finding of tumor metastasis to distant sites supports the notion that the gut microbiome can be considered as an “endocrine gland”, at least when subjected to dysbiosis. Here, NR4A1 is linked to neoplasm.