Around 5% of colorectal cancers occur in individuals who have an inherited mutation.133 Familial adenomatous polyposis is a hereditary condition caused by germline mutations in the adenomatous polyposis coli tumor suppressor gene.134 In this genetic background, numerous adenomatous polyps form in the epithelium of the colon, and malignant transformation may lead to colorectal cancer. This evidence concerns the gene APC and colorectal cancer.