In fact, it is well known that IgG3 subclass half-life is considerably shorter (about one third) than those of the other subclasses [35], and there is some evidence that, in contrast to other respiratory viral infections such as influenza, instead of IgG1, IgG3 appears to be the dominant subtype in SARS-CoV-2 infection [36]. The gene discussed is IGHG3; the disease is influenza.