It was shown that the normal transformed prostate epithelial cell line (RWPE-1) and tumorigenic but non-metastatic Caucasian American (CA) PCa cell lines, LNCaP and 22Rv1, expressed low levels of Snail and vimentin (mesenchymal markers) and high levels of E-cadherin (epithelial marker) [30]. Here, CDH1 is linked to posterior cortical atrophy.