In addition, increased PCa risk has also been associated in men with the SOD2 Ala/Ala genotype who have low antioxidant status [14], high iron intake, or are smokers [23]; yet these men are known to often benefit more from compounds known to reduce oxidative stress, such as pomegranate and muscadine grape skin extract (MSKE) [25]. Here, SOD2 is linked to posterior cortical atrophy.