In 1994, Cugno M. et al. reported that the activation of fibrinolysis, analyzed by measuring the plasma levels of plasmin/alpha-2 antiplasmin complex (PAP), resulted in elevated and continuous AAE with C1-inhibitor deficiency (AAE-C1-INH-) patients. Here, SERPING1 is linked to hyperinsulinemic hypoglycemia, familial, 4.