SGLT2 inhibitors, including dapagliflozin, canagliflozin, ipragliflozin, tofogliflozin, luseogliflozin, sotagliflozin, ertugliflozin and empagliflozin, have been studied in several clinical studies for the treatment of type 2 diabetes mellitus. The gene discussed is SLC5A2; the disease is type 2 diabetes mellitus.