Recently, it has been shown that the ILC2-derived cytokines, IL-5 and GM-CSF, both have the capacity to control tumour development as the genetic ablation of either IL-5 or GM-CSF increased the tumour burden in the MC38 murine CRC model, while overproduction of IL-5 facilitated protection against tumour development [45]. This evidence concerns the gene IL5 and neoplasm.