RAG1 and neoplasm: To this end, we generated subcutaneous MC38 murine colorectal carcinoma syngeneic xenografts in wild-type (C57BL/6) mice, T and B cell-deficient Rag1−/− mice and severely immunocompromised Rag2−/−γc−/− mice, which lack both adaptive and innate lymphoid cells, and compared the tumour growth rates (Figure S1A,B, Table S1).