Using [3H] GnRH as a ligand, Imai et al. detected GnRH-R in RL 95-2 and HHUA EC cancer lines (Kd 2.38 ± 0.86 nM) and in 16 of 18 well differentiated and 4 of 7 poorly differentiated EC specimens (Kd 5.89 ± 3.59 nM). The gene discussed is GNRH1; the disease is cancer.