Antagonists of GnRH-II, however, potently induced apoptosis in human endometrial, ovarian, and breast cancer cells, mediated through activation of stress-induced mitogen activated protein kinases p38 and c-JunNH2-terminal kinase, leading to activation of proapoptotic protein Bax [58,59] (Figure 2). Here, GNRH2 is linked to breast carcinoma.